If he is ready to go, in tip top shape, he can make a big difference. That is if he gets the calls. If you have 3 quality RBs, use them, keeping a fresh RB in the game every series.
Of course, using them correctly would involve high quality OC work, the kind that knows how to adjust play calling to maximize the different strengths of each RB. Do we have that? Or is the approach One Size Fits All?
Play action passing should be stressed - run the RBs, and play action, which combined will set up some open receivers going deep.